Depression symptoms

Persistent low mood, loss of interest, sleep or appetite changes, and low energy lasting 2+ weeks are hallmark depression signs. A provider can evaluate and start treatment online.

Also called: signs of depression · am I depressed · clinical depression

Medically reviewed by Dr. Ikechukwu Ogbu, MD
MD · Board-Certified, Internal Medicine · Last reviewed

Seek urgent care or the ER if you have:

  • Symptoms that are sudden, severe, or rapidly worsening
  • High fever (over 103°F / 39.4°C) that doesn't respond to treatment
  • Chest pain, trouble breathing, fainting, or confusion
  • Signs of dehydration — dizziness, dark urine, unable to keep fluids down
  • Symptoms in someone who is pregnant, immunocompromised, or over 65

What depression symptoms could be

The most common causes a clinician considers. This isn't a diagnosis — it's the differential a provider works through with you.

Depression

Depression is one of the more common causes of depression symptoms. A provider can confirm with the right history, exam, or labs — and start treatment the same day when appropriate.

Anxiety

Anxiety is one of the more common causes of depression symptoms. A provider can confirm with the right history, exam, or labs — and start treatment the same day when appropriate.

Hypothyroidism

Hypothyroidism is one of the more common causes of depression symptoms. A provider can confirm with the right history, exam, or labs — and start treatment the same day when appropriate.

Typical workup

What a clinician usually orders or asks about when someone presents with depression symptoms.

  • PHQ-9 with safety screen for suicidality
  • TSH, CBC, vitamin D, and B12 to rule out common medical contributors
  • Review sleep, substance use, and life stressors alongside medication and therapy options

When to see a clinician

  • Symptoms have lasted more than a few days without improving, or keep coming back
  • You're not sure if this needs antibiotics, prescription treatment, or watchful waiting
  • You have a chronic condition (diabetes, heart disease, immunocompromised) that raises the stakes
  • You want a same-day plan without a trip to urgent care

Common questions