Diarrhea with fatigue and weight loss

Prolonged watery diarrhea with severe fatigue, appetite loss, and weight loss is the classic cyclosporiasis pattern. Cyclospora PCR is the test to ask for — routine stool cultures miss it.

Also called: losing weight from diarrhea · watery diarrhea and exhaustion · cyclospora symptoms

Medically reviewed by Dr. Ikechukwu Ogbu, MD
MD · Board-Certified, Internal Medicine · Last reviewed

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Cyclosporiasis treatment
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Seek urgent care or the ER if you have:

  • Symptoms that are sudden, severe, or rapidly worsening
  • High fever (over 103°F / 39.4°C) that doesn't respond to treatment
  • Chest pain, trouble breathing, fainting, or confusion
  • Signs of dehydration — dizziness, dark urine, unable to keep fluids down
  • Symptoms in someone who is pregnant, immunocompromised, or over 65

What diarrhea with fatigue and weight loss could be

The most common causes a clinician considers. This isn't a diagnosis — it's the differential a provider works through with you.

Cyclosporiasis

Cyclosporiasis is one of the more common causes of diarrhea with fatigue and weight loss. Ondoc can evaluate it online.

Giardiasis

Giardiasis is one of the more common causes of diarrhea with fatigue and weight loss. Ondoc can evaluate it online.

Hypothyroidism

Hypothyroidism is one of the more common causes of diarrhea with fatigue and weight loss. Ondoc can evaluate it online.

Dr. Ikechukwu Ogbu, MD — Medical Director
Dr. Ikechukwu Ogbu, MD

Board-Certified · Internal Medicine · Medical Director

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