Ibuprofen vs Tylenol — can I take together?

Ibuprofen and acetaminophen (Tylenol) have different risks. Combining or alternating them can cause dosing mistakes; check labels for duplicate ingredients and total daily doses. Kidney disease, ulcers, blood thinners, liver disease, heavy alcohol use and pregnancy require specific advice. A clinician or pharmacist can review what is safe for you.

Also called: acetaminophen vs ibuprofen · pain relief combo · safe pain reliever

Medically reviewed by Dr. Ikechukwu Ogbu, MD
MD · Board-Certified, Internal Medicine · Last reviewed

Where this comes up clinically

Conditions this topic is usually discussed alongside. Not a recommendation to start, stop, or change any medication.

Migraines

Commonly relevant for people looking into "Ibuprofen vs Tylenol — can I take together?" — worth reviewing with a clinician who knows your history.

Tension headache

Commonly relevant for people looking into "Ibuprofen vs Tylenol — can I take together?" — worth reviewing with a clinician who knows your history.

Low back pain

Commonly relevant for people looking into "Ibuprofen vs Tylenol — can I take together?" — worth reviewing with a clinician who knows your history.

When to see a clinician

  • You're starting, stopping, or switching a medication and want a clinician's read on side effects
  • You've had a new symptom you think might be medication-related
  • You're due for the lab monitoring this medication requires
  • You want a second opinion on whether the medication is still the right choice

Common questions